BD-1047
Based on 12 publication(s) in Google Scholar
BD-1047 is a selective functional antagonist of sigma receptors. BD-1047 attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches.
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- No. CAS: 138356-20-4
- Fòrmula: C13H20Cl2N2
- Peso molecular:275.22
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) BD-1047
More- Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]
- Mol Med. 2022 Aug 3;28(1):87. [Abstract]
- Cell Rep. 2023 Jan 31;42(1):112011. [Abstract]
- Br J Pharmacol. 2026 Aug;183(15):4178-4195. [Abstract]
- Life Sci. 2020 Sep 15:257:118047. [Abstract]
- Eur J Pharmacol. 2023 May 5:946:175647. [Abstract]
- Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
- Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]
- Mol Neurobiol. 2025 Jun 1. [Abstract]
- Eur J Med Res. 2025 Oct 30;30(1):1041. [Abstract]
- Behav Brain Res. 2025 Apr 27:484:115493. [Abstract]
- Int J Gen Med. 2025 Apr 4:18:1917-1931. [Abstract]
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Ver todos los productos específicos de isoformas Sigma Receptor
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Actividad biológica
Chemical Information
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No. CAS 138356-20-4
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Peso molecular 275.22
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Fòrmula C13H20Cl2N2
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SMILES
CN(C)CCN(CCC1=CC=C(Cl)C(Cl)=C1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
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Journal Impact Factor
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Most Recent
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Neural Regen Res
Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation. [Abstract]2025 Aug 1;20(8):2325-2336. PMID: 39359091
BD-1047 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]
Viability of cells pretreated with or without H2O2, YL, and BD-1047 (BD) for 1 hour.
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Mol Med
Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis. [Abstract]2022 Aug 3;28(1):87. PMID: 35922746 -
Cell Rep
Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. [Abstract]2023 Jan 31;42(1):112011. PMID: 36656708 -
Br J Pharmacol
Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]2026 Aug;183(15):4178-4195. PMID: 42025290 -
Life Sci
Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression. [Abstract]2020 Sep 15:257:118047. PMID: 32629001 -
Eur J Pharmacol
Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). [Abstract]2023 May 5:946:175647. PMID: 36898424 -
Int Immunopharmacol
Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress. [Abstract]2024 Jan 25:127:111382. PMID: 38141412
BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
Western blot results showed that Flv and BD1047 (0.3 mg/kg) alone had no effect on normal rats.
BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
BD1047 (0.3 mg/kg) S1R activation improved myocardial contractility in CLP rats. HE staining showed that S1R activation led to denser myocardial packing and reduced sepsis-induced damage.
BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
ROS immunofluorescence staining showed that S1R activation of BD1047 (5 μM) reduced ROS production in myocardial tissue.
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Int Immunopharmacol
Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. [Abstract]2023 Apr:117:109907. PMID: 36827915
BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]
BD-1047 dihydrobromide significantly decreases the expression of GFAP in astrocytes.
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Mol Neurobiol
Sigma-1 Receptor Activation Alleviates iBRB Dysfunction after I/R Injury by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy. [Abstract]2025 Jun 1. PMID: 40450632 -
Eur J Med Res
Investigation of the mechanism by which sigma-1 receptor protein mediates the IRE1-XBP-1s pathway to alleviate cerebral ischemia-reperfusion injury. [Abstract]2025 Oct 30;30(1):1041. PMID: 41163082 -
Behav Brain Res
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes. [Abstract]2025 Apr 27:484:115493. PMID: 39986614 -
Int J Gen Med
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury. [Abstract]2025 Apr 4:18:1917-1931. PMID: 40201929
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BD-1047 Related Classifications
HY-16996 Related Classifications
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