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Referencia número: HY-178489

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BGC1614

BGC1614 is a Nectin-4-targeting bicyclic toxin conjugate (BTC) belonging to the category of peptide-drug conjugates (PDCs). BGC1614 exhibits strong targeted binding ability to Nectin-4, with an K_D of 3.859 × 10^-7 M. BGC1614 exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts. BGC1614 can be used for research related to Nectin-4-overexpressing tumors (such as prostate cancer, gastric cancer).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₈₇H₅₈₂N₉₄O₁₀₄S₇
Peso molecular:8439.78

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

BGC1614 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vivo

BGC1614 (1.0-3.0 mg/kg, i.v., once a week, 21 days) exhibits superior antitumor efficacy in nude mice bearing PC-3 and N87 tumor xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PC-3 or N87 cells were implanted into nude mice^[1]
Dosage:

1.0, 3.0 mg/kg
Administration:

i.v., once a week, 21 days
Result:

Achieved tumor growth inhibition (TGI) rates of 96.3% in nude mice bearing PC-3 tumor xenografts.
Achieved tumor growth inhibition (TGI) rates of 41.9% and 70.1% respectively in nude mice bearing N87 tumor xenografts.
Showed no significant changes in body weight.

Chemical Information

Peso molecular 8439.78
Fòrmula C₃₈₇H₅₈₂N₉₄O₁₀₄S₇
Sequence

Mpa-Pro-Nal-(DAsp)-Cys-Met-hArg-Asp-Trp-Ser-Thr-Pro-HyP-Trp-Cys(TATA covalent with Mpa1,Cys5,Cys15)-Sar10-PEG6-Lys(Lys(N3)-(DBCO-PEG6-βAla-Sar10-Ala-hArg-Asp-Cys-Hyp-Leu-Val-Asn-Pro-Leu-Cys-Leu-His-Pro-(DAsp)-Trp-hArg-Cysteamine, TATA covalent with Cys15,Cys22,Cysteamine 29)-GA-Val-Cit-PABC-MMAE
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gu JN, et al. Design, synthesis and antitumor evaluation of a novel nectin-4 targeting bicyclic toxin conjugate. Bioorg Med Chem Lett. 2025 Nov 1;127:130306. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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