BPH-1086
BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1226901-43-4
- Fòrmula: C4H8O7P2
- Peso molecular:230.05
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
Target: IspH[1]
In Vitro
IspH (LytB) is the last enzyme in the nonmevalonate pathway, IspH domains can be fused to either the ribosomal protein S1 (RPS1), IspH–RPS1 binds to mRNA or forms part of the bacterial ribosome[1][2].
IspH–RPS1 proteins are present in anaerobes found in the human gut and some, such as Clostridium botulinum, C. tetani and Fusobacterium nucleatum, are pathogens[2].
IspH inhibitor will therefore kill bacteria directly, as with other antibiotics, but will also kill persistent bacteria by microptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1226901-43-4
-
Peso molecular 230.05
-
Fòrmula C4H8O7P2
-
SMILES
O=P(O)(OP(O)(O)=O)OCC#CC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (268 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Wang W, et al. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. [Content Brief]
[2]. Rao G, et al. IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins. Chem Sci. 2015 Dec 1;6(12):6813-6822. [Content Brief]
[3]. Singh KS, et al. IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance. Nature. 2021 Jan. 589(7843):597-602. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BPH-1086 Related Classifications
HY-147304 Related Classifications
Powered by Bioz