CL2A
Based on 1 Customer Validation
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.
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- No. CAS: 2616704-22-2
- Fòrmula: C50H79N9O16
- Peso molecular:1062.21
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2616704-22-2
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Appearance Solid-Liquid Mixture
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Peso molecular 1062.21
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Fòrmula C50H79N9O16
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Color Colorless to light yellow
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SMILES
O=C(NC1=CC=C(CO)C=C1)[C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (94.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9414 mL | 4.7072 mL | 9.4143 mL | 23.5358 mL |
| 5 mM | 0.1883 mL | 0.9414 mL | 1.8829 mL | 4.7072 mL | |
| 10 mM | 0.0941 mL | 0.4707 mL | 0.9414 mL | 2.3536 mL | |
| 15 mM | 0.0628 mL | 0.3138 mL | 0.6276 mL | 1.5691 mL | |
| 20 mM | 0.0471 mL | 0.2354 mL | 0.4707 mL | 1.1768 mL | |
| 25 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9414 mL | |
| 30 mM | 0.0314 mL | 0.1569 mL | 0.3138 mL | 0.7845 mL | |
| 40 mM | 0.0235 mL | 0.1177 mL | 0.2354 mL | 0.5884 mL | |
| 50 mM | 0.0188 mL | 0.0941 mL | 0.1883 mL | 0.4707 mL | |
| 60 mM | 0.0157 mL | 0.0785 mL | 0.1569 mL | 0.3923 mL | |
| 80 mM | 0.0118 mL | 0.0588 mL | 0.1177 mL | 0.2942 mL |
CL2A Related Classifications
HY-128945 Related Classifications
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