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Referencia número: HY-14176R

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Compound E (Standard)

Name: Compound E (Standard)
Brand: MedChemExpress
SKU: HY-14176R
Availability: PreOrder

(Synonyms: γ-Secretase-IN-1 (Standard))

Compound E (Standard) is the analytical standard of Compound E (HY-14176). This product is intended for research and analytical applications. Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀s of 0.24, 0.37, 0.32 nM, respectively.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 209986-17-4
Fòrmula: C₂₇H₂₄F₂N₄O₃
Peso molecular:490.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Compound E (Standard) Chemical Structure

No. CAS: 209986-17-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Information
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Product Information

Information

Aplicación

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

No. CAS 209986-17-4
Peso molecular 490.50
Fòrmula C₂₇H₂₄F₂N₄O₃
SMILES

FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1
Synonyms

γ-Secretase-IN-1 (Standard)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402. [Content Brief]

[2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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