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Referencia número: HY-181829

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Ctx-L3

Ctx-L3 is a selective EGFR PTAC (PSMA-targeted chimera) degrader (DC₅₀: 4.3 pM in LNCaP cells) and LYTAC. Ctx-L3 recruits prostate-specific membrane antigen (PSMA) and mediates lysosomal degradation of EGFR in PSMA-positive prostate cancer cells. Ctx-L3 exhibits degrading activity against EGFR in prostate cancer cells. Ctx-L3 is applicable to related research on prostate cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₇₂H₁₁₄N₁₀O₂₇
Peso molecular:1551.73

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ctx-L3 Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas EGFR :

In Vitro

Ctx-L3 (0.01-100 nM; 24 h) potently and selectively induces lysosomal degradation of EGFR in PSMA-positive prostate cancer cell lines, with a DC₅₀ of 4.3 pM in LNCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 1551.73
Fòrmula C₇₂H₁₁₄N₁₀O₂₇
SMILES

O=C(CCC(NCCOCCOCCOCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)N(C1=C2C=CC=C1)CC(C=CC=C3)=C3C4=C2N=NN4CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Cai D, et al. Development of Prostate-Specific Lysosome-Targeting Degraders. J Am Chem Soc. 2026;148(7):7171-7180. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Ctx-L3

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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Ctx-L3 Related Classifications

HY-181829 Related Classifications