CYY292
Based on 1 Customer Validation
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.19%
- No. CAS: 2644673-04-9
- Fòrmula: C24H28N8O
- Peso molecular:444.53
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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Anti-Lung Cancer Compound Library
HY-L075
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Angiogenesis-Related Compound Library
HY-L088
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Anti-Liver Cancer Compound Library
HY-L101
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Anti-Prostate Cancer Compound Library
HY-L124
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Cytokine Inhibitors Library
HY-L161
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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Anti-Fibrosis Compound Library
HY-L185
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Anti-Brain Cancer Compound Library
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Protein Kinase Compound Library
HY-L196
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Actividad biológica
FGFR1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HOS-TE85 | IC50 |
1.36 μM
Compound: 7l
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Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| MG-63 | IC50 |
0.84 μM
Compound: 7l
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Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| SAOS-2 | IC50 |
0.72 μM
Compound: 7l
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Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
| U2OS | IC50 |
0.76 μM
Compound: 7l
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Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35239349] |
Chemical Information
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No. CAS 2644673-04-9
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Appearance Solid
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Peso molecular 444.53
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Fòrmula C24H28N8O
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Color White to off-white
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SMILES
CN1CCN(C2=C(OC)C=C(NC3=NC(NC4=CC(NN=C5)=C5C=C4)=C(C)C=N3)C=C2)CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYY292 Related Classifications
HY-162153 Related Classifications
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