Referencia número: HY-N7640

Deoxylimonin

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Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound.

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Pureza: 99.51%
No. CAS: 989-23-1
Fòrmula: C₂₆H₃₀O₇
Peso molecular:454.51

Almacenamiento:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Deoxylimonin Chemical Structure

No. CAS: 989-23-1

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Precio

Stock

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	5.5 μM Compound: 11d	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay	[PMID: 33289552]
MDA-MB-435	IC₅₀	1.7 μM Compound: 11d	Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay	[PMID: 33289552]

In Vitro

Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

MDA-MB-435 and MCF-7 cells
Concentration:

0-90 μg/mL
Incubation Time:

48 hours
Result:

Showed IC₅₀ values of 0.78 μg/mL and 2.50 μg/mL for MDA-MB-435 and MCF-7 cells, respectively.

In Vivo

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice injected with acetic acid^[1]
Dosage:

70 mg/kg
Administration:

Oral administration; 70 mg/kg; once
Result:

Showed the antinociception efficacy (writhing inhibition rate: 24.61%).

Chemical Information

No. CAS 989-23-1
Appearance Solid
Peso molecular 454.51
Fòrmula C₂₆H₃₀O₇
Color White to off-white
SMILES

C[C@]1(C2=CC3=O)[C@@](CC[C@]2([C@@](C4=COC=C4)([H])O3)C)([H])[C@]([C@@](C5)([H])OC(C)6C)(COC5=O)[C@@]6([H])CC1=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Microorganisms
Acinetobacter species
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (220.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2002 mL

11.0009 mL

22.0017 mL

5 mM

0.4400 mL

2.2002 mL

4.4003 mL

10 mM

0.2200 mL

1.1001 mL

2.2002 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (284 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shaochi Wang, et al. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs. Bioorg Chem. 2020 Jul;100:103886. [Content Brief]

[2]. N. Guthri, et al. Inhibition of Human Breast Cancer Cells by Citrus Limonoids. ACS Symposium SeriesVol. 758, July 30, 2000.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2002 mL	11.0009 mL	22.0017 mL	55.0043 mL
	5 mM	0.4400 mL	2.2002 mL	4.4003 mL	11.0009 mL
	10 mM	0.2200 mL	1.1001 mL	2.2002 mL	5.5004 mL
	15 mM	0.1467 mL	0.7334 mL	1.4668 mL	3.6670 mL
	20 mM	0.1100 mL	0.5500 mL	1.1001 mL	2.7502 mL
	25 mM	0.0880 mL	0.4400 mL	0.8801 mL	2.2002 mL
	30 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8335 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3751 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1001 mL
	60 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6876 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5500 mL

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Deoxylimonin

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

Terpenoids Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Microbial Metabolite Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Deoxylimonin

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

Terpenoids Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Microbial Metabolite Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Deoxylimonin Related Classifications

HY-N7640 Related Classifications