DG 381B
DG 381B (compound 62) is a 11β-HSD1 and 11β-HSD2inhibitor.
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- No. CAS: 564-16-9
- Fòrmula: C30H48O3
- Peso molecular:456.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
161.68 μM
Compound: 42, 11-deoxo-GA
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Cytotoxicity against human HepG2(2.2.15) cells
Cytotoxicity against human HepG2(2.2.15) cells
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[PMID: 22520261] |
| HepG2 2.2.15 | IC50 |
>1374.78 μM
Compound: 42, 11-deoxo-GA
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release
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[PMID: 22520261] |
| HepG2 2.2.15 | IC50 |
47 μM
Compound: 42, 11-deoxo-GA
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication
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[PMID: 22520261] |
| HepG2 2.2.15 | IC50 |
48.66 μM
Compound: 42, 11-deoxo-GA
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Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B surface antigen release
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B surface antigen release
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[PMID: 22520261] |
| RAW264.7 | IC50 |
25.61 μM
Compound: 5
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
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[PMID: 32299661] |
| Sf21 | IC50 |
>40 μM
Compound: 8
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Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
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[PMID: 31774676] |
Chemical Information
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No. CAS 564-16-9
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Peso molecular 456.70
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Fòrmula C30H48O3
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SMILES
C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DG 381B Related Classifications
HY-169739 Related Classifications
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