country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-D3200

Copy Link Print Information

Dns–LLC

Dns-LLC is a cell-permeable Cu⁺-selective fluorescent probe that forms a 1:1 complex with Cu⁺. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu⁺ in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu⁺ in the Golgi apparatus.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3112200-59-3
Fòrmula: C₂₇H₄₁N₅O₅S₂
Peso molecular:579.77

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dns–LLC Chemical Structure

No. CAS: 3112200-59-3

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

Dns-LLC (10 μM) forms a 1:1 complex with Cu⁺ in buffered aqueous solution at physiological pH, exhibits approximately 12-fold fluorescence turn-on enhancement towards Cu⁺, and has a femtomolar-level binding affinity (K_d=12 fM)^[1].
Dns-LLC (20 μM; 30 min) penetrates live human colorectal RKO cells, selectively detects intracellular Cu⁺ via a turn-on fluorescence response, localizes to the Golgi apparatus to detect Cu⁺ in this organelle, and exhibits no obvious cytotoxicity against RKO cells^[1].
Dns-LLC holds potential for the study of cuproptosis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3112200-59-3
Peso molecular 579.77
Fòrmula C₂₇H₄₁N₅O₅S₂
SMILES

CN(C)C(C1=CC=C2)=CC=CC1=C2S(=O)(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N)=O)=O)=O)CC(C)C)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jung KH, et al. Development of new peptide-based receptor of fluorescent probe with femtomolar affinity for Cu(+) and detection of Cu(+) in Golgi apparatus. Biosens Bioelectron. 2016;85:437-444. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto