DSPE-PEG2000-ALK

DSPE-PEG2000-ALK is mainly used for click chemistry-mediated carrier surface functionalization research.
Structural composition and the role of each component:
(1) DSPE: 1,2-distearate-sn-glycerol-3-phosphoethanolamine, containing two saturated C18 stearoyl chains, is an amphiphilic phospholipid. As a lipid anchoring group, it can stably insert into the lipid bilayer of liposomes or lipid nanoparticles, anchoring the entire molecule to the carrier surface;
(2) PEG2000: Polyethylene glycol with a molecular weight of approximately 2000 Da, acting as a hydrophilic spacer arm, can enhance the water solubility and steric hindrance of the molecule, improve the stability of the carrier, and prolong its circulation time in vivo. Simultaneously, it extends the terminal ligand away from the carrier surface, facilitating the recognition and binding of the ligand and receptor;
(3) Alkyne end group: The alkyne group can undergo a copper-catalyzed azido-alkyne cycloaddition reaction (click chemistry) with azides, achieving efficient connection with azide-modified molecules.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.