EIDD-036
EIDD-036, is the blood-brain barrier penetrant C-20 oxime of Progesterone (HY-N0437), that binds progesterone receptor (PR) with an IC50 of 171 nM. EIDD-036 is the active metabolite of EIDD-1723 (HY-125547). EIDD-036 exhibits promising challenges for rapid administration in acute trauma. EIDD-036 can be used for the study of traumatic brain injury (TBI).
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- No. CAS: 211302-60-2
- Fòrmula: C21H31NO2
- Peso molecular:329.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
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Help & FAQs
Actividad biológica
Descripciòn
Parmacokinetics
In Vivo
Chemical Information
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No. CAS 211302-60-2
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Peso molecular 329.48
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Fòrmula C21H31NO2
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SMILES
C[C@@]12[C@](CC[C@@H]2/C(C)=N/O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
[1]. Wali B, et al. Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats. Neuropharmacology. 2016 Oct;109:148-158. [Content Brief]
[2]. Fritzemeier RG, et al. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66(8):5397-5414. [Content Brief]
[3]. Sayeed I, et al. Development of a novel progesterone analog in the treatment of traumatic brain injury. Neuropharmacology. 2019 Feb;145(Pt B):292-298. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EIDD-036 Related Classifications
HY-17649 Related Classifications
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