Ergosterol peroxide
Based on 1 publication(s) in Google Scholar
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities.
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- Pureza : 99.57%
- No. CAS: 2061-64-5
- Fòrmula: C28H44O3
- Peso molecular:428.65
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ergosterol peroxide
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
14.32 μg/mL
Compound: 5
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 23511021] |
| B16 | IC50 |
77.9 μM
Compound: 6
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Cytotoxicity against murine B16 cells by MTT assay
Cytotoxicity against murine B16 cells by MTT assay
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[PMID: 17256903] |
| BV-2 | IC50 |
6.3 μM
Compound: 22
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Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
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[PMID: 21028898] |
| HEK293 | EC50 |
0.85 μM
Compound: 2
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Agonist activity at full length mouse FXR/RXRalpha expressed in human HEK293 cells assessed as induction of transcriptional activity after 18 hrs by dual luciferase reporter gene assay
Agonist activity at full length mouse FXR/RXRalpha expressed in human HEK293 cells assessed as induction of transcriptional activity after 18 hrs by dual luciferase reporter gene assay
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[PMID: 22014750] |
| HeLa | IC50 |
19.54 μM
Compound: Ergosterol peroxide
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Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
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[PMID: 38107170] |
| Hep 3B2 | IC50 |
16.51 μg/mL
Compound: 5
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Cytotoxicity against human Hep3B cells
Cytotoxicity against human Hep3B cells
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[PMID: 23511021] |
| HepG2 | IC50 |
15.27 μg/mL
Compound: 5
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Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
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[PMID: 23511021] |
| HepG2 | IC50 |
23.35 μM
Compound: Ergosterol peroxide
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38107170] |
| KB | ED50 |
9.79 μg/mL
Compound: 4
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Cytotoxicity against human KB cells after 4 days
Cytotoxicity against human KB cells after 4 days
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[PMID: 1791484] |
| MCF7 | IC50 |
13.41 μg/mL
Compound: 5
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 23511021] |
| MCF7 | IC50 |
18 μM
Compound: Ergosterol peroxide
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by CCK8 assay
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[PMID: 38107170] |
| MDA-MB-231 | IC50 |
16.74 μg/mL
Compound: 5
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Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
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[PMID: 23511021] |
| PLC-PRF-5 | ED50 |
10.99 μg/mL
Compound: 4
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Cytotoxicity against human PLC/PRF/5 cells after 4 days
Cytotoxicity against human PLC/PRF/5 cells after 4 days
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[PMID: 1791484] |
| RAW264.7 | IC50 |
28.7 μM
Compound: 117
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
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[PMID: 31255927] |
| RAW264.7 | IC50 |
9.4 μM
Compound: 9
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by Griess reaction method
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[PMID: 23357630] |
| SNU1 | IC50 |
18.7 μM
Compound: 231
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Cytotoxicity against human SNU1 cells
Cytotoxicity against human SNU1 cells
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[PMID: 17618015] |
| SNU-354 | IC50 |
158.2 μM
Compound: 231
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Cytotoxicity against human SNU354 cells
Cytotoxicity against human SNU354 cells
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[PMID: 17618015] |
| SNU-C4 | IC50 |
84.6 μM
Compound: 231
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Cytotoxicity against human SNUC4 cells
Cytotoxicity against human SNUC4 cells
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[PMID: 17618015] |
Chemical Information
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No. CAS 2061-64-5
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Appearance Solid
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Peso molecular 428.65
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Fòrmula C28H44O3
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@]4(C=C[C@]1(C[C@H](CC2)O)OO4)[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)/C=C/[C@H](C)C(C)C)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
In Vitro:
DMSO : 12.5 mg/mL (29.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ming Bu, et al. Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity. Molecules. 2019 Sep 11;24(18):3307 [Content Brief]
[2]. Taotao Ling, et al. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 May 29;17(21):5223-5229. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3329 mL | 11.6645 mL | 23.3291 mL | 58.3226 mL |
| 5 mM | 0.4666 mL | 2.3329 mL | 4.6658 mL | 11.6645 mL | |
| 10 mM | 0.2333 mL | 1.1665 mL | 2.3329 mL | 5.8323 mL | |
| 15 mM | 0.1555 mL | 0.7776 mL | 1.5553 mL | 3.8882 mL | |
| 20 mM | 0.1166 mL | 0.5832 mL | 1.1665 mL | 2.9161 mL | |
| 25 mM | 0.0933 mL | 0.4666 mL | 0.9332 mL | 2.3329 mL |
Ergosterol peroxide Related Classifications
HY-N3845 Related Classifications
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