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Referencia número: HY-131914

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EST64454

EST64454 (compound 9k) is a selective, orally active sigma-1 receptor antagonist with K_i 22 nM. EST64454 can be used to study pain.

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No. CAS: 1351438-26-0
Fòrmula: C₁₈H₂₂F₂N₄O₂
Peso molecular:364.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

EST64454 Chemical Structure

No. CAS: 1351438-26-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

EST64454 (compound 9k) is a selective, orally active sigma-1 receptor antagonist with K_i 22 nM. EST64454 can be used to study pain^[1].

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σ1R

22 nM (Ki)

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Chemical Information

No. CAS 1351438-26-0
Peso molecular 364.39
Fòrmula C₁₈H₂₂F₂N₄O₂
SMILES

CC(N1CCN(CCOCC2=NN(C3=CC=C(F)C(F)=C3)C=C2)CC1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yeste S, et al. Preliminary in Vitro Assessment of the Potential of EST64454, a Sigma-1 Receptor Antagonist, for Pharmacokinetic Drug-Drug Interactions. Biol Pharm Bull. 2020;43(1):68-76. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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EST64454

Ver todos los productos específicos de isoformas Sigma Receptor

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