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Referencia número: HY-P99288

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Biologically Validated

FG-3019

Name: FG-3019
Brand: MedChemExpress
SKU: HY-P99288
Price: 170.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: Pamrevlumab; Anti-Human CTGF Recombinant Antibody)

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: ≥99.0%
No. CAS: 946415-13-0
Peso molecular:144.86 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

FG-3019 Chemical Structure

No. CAS: 946415-13-0

Tamaño

Precio

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Cantidad

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Verified Bioactivity
Chemical Information
Publications (2)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)^[1]^[2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CTGF

In Vivo

FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) in combination with Gemcitabine acutely decreases mouse pancreatic ductal adenocarcinoma (PDA) growth and induces neoplastic cell apoptosis in LSL-Kras^G12D/+;LSL-Trp53^R172H/+;Pdx-1-Cre (KPC) mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

1490 [NCBI]

Accession

P29279

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Aplicación

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized CCN2/CTGF Protein, Human can bind Pamrevlumab . The EC₅₀ for this effect is 6.731 ng/mL.

Chemical Information

No. CAS 946415-13-0
Appearance Liquid
Peso molecular 144.86 kDa
Color Colorless to light yellow
SMILES

[FG-3019]
Synonyms

Pamrevlumab; Anti-Human CTGF Recombinant Antibody
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All WBHistological Imaging/Staining

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Journal Impact Factor

Nat Commun

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. [Abstract]

2025 Sep 30;16(1):8710. PMID: 41027873
Acta Pharm Sin B

2026 Feb 26.

FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.

Wild-type (WT) mice were treated with PBS, and Mdx mice were treated with PBS, FG-3019 (50 mg/kg), TGF-β1 antibody (TGF-β1 ab), FG-3019 + TGF-β1 antibody (CTGF + F + T), and IgG for 6 weeks. Western blot analysis of myofibril and collagen III levels was then performed.

FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.

Masson staining was used to detect the diaphragm of wild-type (WT) mice treated with PBS, and mdx mice treated with PBS, Apc003OA, FG-3019 (50 mg/kg), Apc003OA+BP, and BP.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. [Content Brief]

[2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

FG-3019

2 Cited Publications

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Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
- Biological Activity
Chemical Information
Publications (2)
Pureza y Documentación
Referencias

1/16

Human IgG1 kappa
1/16

Immobilized CCN2/CTGF Protein, Human can bind Pamrevlumab . The EC₅₀ for this effect is 6.731 ng/mL.
1/16

FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.

Customer Validation
Wild-type (WT) mice were treated with PBS, and Mdx mice were treated with PBS, FG-3019 (50 mg/kg), TGF-β1 antibody (TGF-β1 ab), FG-3019 + TGF-β1 antibody (CTGF + F + T), and IgG for 6 weeks. Western blot analysis of myofibril and collagen III levels was then performed.
1/16

FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.

Customer Validation
Masson staining was used to detect the diaphragm of wild-type (WT) mice treated with PBS, and mdx mice treated with PBS, Apc003OA, FG-3019 (50 mg/kg), Apc003OA+BP, and BP.
1/16

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FG-3019

Publications Citing Use of MedChemExpress (MCE) FG-3019