Gap19 TFA
Based on 5 publication(s) in Google Scholar
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.
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- Pureza: 99.97%
- Fòrmula: C57H97F3N14O15
- Peso molecular:1275.46
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Gap19 TFA
More
Actividad biológica
Cx43 Hemichannel[1]
Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 TFA (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/BL6 mice[2]
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Dosage:25 mg/kg
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Administration:IV; 10 min before ligation
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Result:Significantly reduced the infarct size by approximately one-fifth.
Chemical Information
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Appearance Solid
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Peso molecular 1275.46
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Fòrmula C57H97F3N14O15
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Color White to off-white
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Sequence Shortening
KQIEIKKFK
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
A potential therapeutic target at Connexin 43 serine phosphorylation against ischaemia/reperfusion arrhythmia. [Abstract]2025 Jun 9. PMID: 40490933 -
Cell Stress Chaperones
Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. [Abstract]2024 Jun;29(3):440-455. PMID: 38653383 -
Oral Dis
Connexin43 reduces LPS-induced inflammation in hDPCs through TLR4-NF-κB pathway via hemichannels. [Abstract]2024 Jul;30(5):3239-3249. PMID: 37811593 -
Brain Res
Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke. [Abstract]2023 Dec 15:1821:148619. PMID: 37805009 -
Solvente y solubilidad
DMSO : 100 mg/mL (78.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (78.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (78.40 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73. [Content Brief]
[2]. Wang N, et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.7840 mL | 3.9202 mL | 7.8403 mL | 19.6008 mL |
| 5 mM | 0.1568 mL | 0.7840 mL | 1.5681 mL | 3.9202 mL | |
| 10 mM | 0.0784 mL | 0.3920 mL | 0.7840 mL | 1.9601 mL | |
| 15 mM | 0.0523 mL | 0.2613 mL | 0.5227 mL | 1.3067 mL | |
| 20 mM | 0.0392 mL | 0.1960 mL | 0.3920 mL | 0.9800 mL | |
| 25 mM | 0.0314 mL | 0.1568 mL | 0.3136 mL | 0.7840 mL | |
| 30 mM | 0.0261 mL | 0.1307 mL | 0.2613 mL | 0.6534 mL | |
| 40 mM | 0.0196 mL | 0.0980 mL | 0.1960 mL | 0.4900 mL | |
| 50 mM | 0.0157 mL | 0.0784 mL | 0.1568 mL | 0.3920 mL | |
| 60 mM | 0.0131 mL | 0.0653 mL | 0.1307 mL | 0.3267 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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