Errfi1 - ERBB receptor feedback inhibitor 1 Gene

Also Known as Mig6; RALT; Mig-6; 1300002F13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74155

Summary

Predicted to enable SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including lung development; negative regulation of epidermal growth factor-activated receptor activity; and skin morphogenesis. Located in cytoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in alveolar system; lung; and lung epithelium. Used to study endometrial Cancer and osteoarthritis. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Errfi1 Products (2)

mRNA Protein Name
NM_001356323.1 NP_001343252.1 ERBB receptor feedback inhibitor 1
NM_133753.2 NP_598514.1 ERBB receptor feedback inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within apoptotic process IDA
IDA: Inferred from direct assay
22975324 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
20418913 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
22975324 MGI
acts upstream of or within bile acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
22912762 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
24550287 MGI
acts upstream of or within cell cycle IMP
IMP: Inferred from mutant phenotype
25976672 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
16247031 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
16247031 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
22912762 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
22912762 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
24550287 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
20018910 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19683494 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22136853 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
25976672 MGI
acts upstream of or within epithelium development IMP
IMP: Inferred from mutant phenotype
16819504 MGI
acts upstream of or within fat pad development IMP
IMP: Inferred from mutant phenotype
28053990 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
20418913 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
19439667 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
28053990 MGI
acts upstream of or within limb joint morphogenesis IMP
IMP: Inferred from mutant phenotype
24550287 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
22912762 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
22912762 MGI
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
19710174 MGI
involved in lung epithelium development IMP
IMP: Inferred from mutant phenotype
19710174 MGI
involved in lung vasculature development IMP
IMP: Inferred from mutant phenotype
19710174 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19710174 MGI
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: Inferred from mutant phenotype
16648858 MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
20418913 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
29843645 MGI
acts upstream of or within progesterone receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25976672 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22136853 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
29843645 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22136853 MGI
involved in regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
16648858 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
29843645 MGI
acts upstream of or within regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
22975324 MGI
acts upstream of or within regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
20018910 MGI
acts upstream of or within response to 1-oleoyl-sn-glycerol 3-phosphate IDA
IDA: Inferred from direct assay
19683494 MGI
acts upstream of or within response to estradiol IDA
IDA: Inferred from direct assay
20018910 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
28053990 MGI
acts upstream of or within response to progesterone IDA
IDA: Inferred from direct assay
20018910 MGI
acts upstream of or within response to progesterone IMP
IMP: Inferred from mutant phenotype
25976672 MGI
acts upstream of or within response to steroid hormone IMP
IMP: Inferred from mutant phenotype
19439667 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
19683494 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
17987665 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17987665 MGI
involved in skin morphogenesis IMP
IMP: Inferred from mutant phenotype
16648858 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
19439667 MGI
acts upstream of or within uterine epithelium development IMP
IMP: Inferred from mutant phenotype
19439667 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
17987665 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16648858 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16648858 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ERBB receptor feedback inhibitor 1

  • mitogen-inducible gene 6 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS04516 ERRFI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19775 Errfi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26272 Errfi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Errfi1 NCBI NCBI:54206