Helveticoside
Based on 1 Customer Validation
Helveticoside (Strophanthidin-digitoxoside) is a helveticosid, possesses an ED50 of 0.17 μM for isolated guinea-pig ileum. Helveticoside has anticancer effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 630-64-8
- Fòrmula: C29H42O9
- Peso molecular:534.64
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Chemical Information
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No. CAS 630-64-8
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Appearance Solid
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Peso molecular 534.64
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Fòrmula C29H42O9
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Color White to off-white
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SMILES
O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@H](CC2)O[C@H]4C[C@@H]([C@@H]([C@H](O4)C)O)O)O)([H])[C@@]5([C@](CC3)([C@@H](C(CO6)=CC6=O)CC5)C)O
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Synonyms
Strophanthidin-digitoxoside
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (93.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. K O Haustein, et al. Structure-activity relationship of natural and semi-synthetic genins and glycosides as investigated on the smooth muscle of the guinea-pig ileum. Pharmacology. 1973;10(2):65-75. [Content Brief]
[2]. An N, et al. Helveticoside Exhibited p53-dependent Anticancer Activity Against Colorectal Cancer. Arch Med Res. 2020 Apr;51(3):224-232. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8704 mL | 9.3521 mL | 18.7042 mL | 46.7604 mL |
| 5 mM | 0.3741 mL | 1.8704 mL | 3.7408 mL | 9.3521 mL | |
| 10 mM | 0.1870 mL | 0.9352 mL | 1.8704 mL | 4.6760 mL | |
| 15 mM | 0.1247 mL | 0.6235 mL | 1.2469 mL | 3.1174 mL | |
| 20 mM | 0.0935 mL | 0.4676 mL | 0.9352 mL | 2.3380 mL | |
| 25 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL | 1.8704 mL | |
| 30 mM | 0.0623 mL | 0.3117 mL | 0.6235 mL | 1.5587 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1690 mL | |
| 50 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9352 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5845 mL |
Helveticoside Related Classifications
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