Hericenone D
Based on 1 Customer Validation
Hericenone D, an orally active pancreatic lipase inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.20%
- No. CAS: 137592-04-2
- Fòrmula: C37H58O6
- Peso molecular:598.85
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
Hericenone D (3-100 μM; 24 h) does not exhibit significant neuroprotective activity against Tunicamycin (HY-A0098) or Thapsigargin (HY-13433)-induced ER stress-dependent cell death in murine neuroblastoma Neuro2a cells[1].
Hericenone D (400 μg/mL; 30 min) exhibits significant pancreatic lipase inhibitory activity in a cell-free biochemical assay at a concentration of 400 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:murine neuroblastoma Neuro2a cells
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Concentration:3 μM; 10 μM; 30 μM
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Incubation Time:24 h
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Result:Did not exhibit significant neuroprotective activity against Tunicamycin or Thapsigargin-induced ER stress-dependent cell death.
Hericenone D (p.o.; 42 days) significantly reduces visceral and subcutaneous fat, decreases adipose tissue, increases lipid excreted from feces in female C57BL/6JJcl mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6JJcl mice (female; 12 weeks old)[1]
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Dosage:~0.09 g/day
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Administration:p.o.; 14 days
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Result:Significantly reduced white adipose tissue in the visceral and subcutaneous fat.
Decreased fat tissue around the uterus and the kidney.
Significantly decreased the levels of total cholesterol and leptin in the plasma parameters.
Chemical Information
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No. CAS 137592-04-2
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Appearance Solid
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Peso molecular 598.85
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Fòrmula C37H58O6
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC(/C=C(C)\C)=O)C=O)=O
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Structure Classification
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Initial Source
Hericium erinaceus
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kobayashi S, et al. Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C-H and Their Derivatives. J Org Chem. 2021;86(3):2602-2620. [Content Brief]
[2]. Hiraki E, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71(3):482-491. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hericenone D Related Classifications
HY-N15385 Related Classifications
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