HS024 TFA
Based on 1 publication(s) in Google Scholar
HS024 TFA is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 TFA blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 TFA induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 TFA can be used in research related to MC4 receptor-mediated diseases, such as eating disorders.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.80%
- Fòrmula: C58H79N19O10S2·xC2HF3O2
- Peso molecular:1266.50 (free base)
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HS024 TFA
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
MC4R 0.29 nM (Ki) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
HS024 (0.02-0.1 nmol; i.c.v.; single injection 20 min before testing) TFA does not alter exploratory/locomotor activity in the elevated plus maze or open field[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Peso molecular 1266.50 (free base)
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Fòrmula C58H79N19O10S2·xC2HF3O2
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Color White to off-white
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Sequence
Ac-Cys-{Nle}-Arg-His-{D-2Nal}-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge:Cys1-Cys9)
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Sequence Shortening
Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release. [Abstract]2026 Jan 23;23(1):70. PMID: 41578331
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (Need ultrasonic)
Pureza y Documentación
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Ficha de datos (295 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HS024 TFA Related Classifications
HY-P1215A Related Classifications
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