HS56
Based on 1 Customer Validation
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and >100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.6%
- No. CAS: 922050-57-5
- Fòrmula: C13H8ClN5OS
- Peso molecular:317.75
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Actividad biológica
|
PIM3 0.208 μM (Ki) |
PIM1 2.94 μM (Ki) |
PIM2 >100 μM (Ki) |
HS56 (50 μM; 16 h) delays force onset, decreases contractile force, and reduces LC20 phosphorylation in excised rat caudal arterial VSM tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:VSM tissues
-
Concentration:50 μM
-
Incubation Time:16 hours
-
Result:Modulated LC20 phosphorylation in VSM tissues.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Spontaneously hypertensive renin transgene and wild-type (WT) mice[1]
-
Dosage:10 and 20 mg/kg
-
Administration:Intravenous injection, single injection
-
Result:Induced dose-dependent decreases in systolic blood pressure.
Chemical Information
-
No. CAS 922050-57-5
-
Appearance Solid
-
Peso molecular 317.75
-
Fòrmula C13H8ClN5OS
-
Color White to off-white
-
SMILES
N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
-
Ficha de datos (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)