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Referencia número: HY-A0160

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Indalpine

Name: Indalpine
Brand: MedChemExpress
SKU: HY-A0160
Availability: PreOrder

(Synonyms: LM 5008)

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing ³H-5-HT bound to brain membranes with the IC₅₀ of 36 μM. Indalpine, two antidepressant agent.

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No. CAS: 63758-79-2
Fòrmula: C₁₅H₂₀N₂
Peso molecular:228.33

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Indalpine Chemical Structure

No. CAS: 63758-79-2

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Actividad biológica

Descripciòn

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing ³H-5-HT bound to brain membranes with the IC₅₀ of 36 μM^[1]. Indalpine, two antidepressant agent^[2].

In Vivo

In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 63758-79-2
Peso molecular 228.33
Fòrmula C₁₅H₂₀N₂
SMILES

C1(CCC2CCNCC2)=CNC3=C1C=CC=C3
Synonyms

LM 5008
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104. [Content Brief]

[2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Indalpine

Duloxetine hydrochloride

Venlafaxine hydrochloride

Fluvoxamine maleate

Dapoxetine hydrochloride

ZZL-7

Venlafaxine hydrochloride (Standard)

Adoxosidic acid

Citalopram-d4 hydrobromide

(S)-Venlafaxine

Ampreloxetine hydrochloride

Duloxetine-d7

Duloxetine hydrochloride (Standard)

Actividad biológica

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Indalpine

Duloxetine hydrochloride

Venlafaxine hydrochloride

Fluvoxamine maleate

Dapoxetine hydrochloride

ZZL-7

Venlafaxine hydrochloride (Standard)

Adoxosidic acid

Citalopram-d4 hydrobromide

(S)-Venlafaxine

Ampreloxetine hydrochloride

Duloxetine-d7

Duloxetine hydrochloride (Standard)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Indalpine Related Classifications

HY-A0160 Related Classifications

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