country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-107992

Copy Link Print Information

Iotrolan

Iotrolan is a non-ionic contrast agent. Iotrolan induces Apoptosis. Iotrolan decreases glomerular filtration rate and renal perfusate flow, increases urine flow, and does not significantly decrease fractional sodium reabsorption. Iotrolan can be used in studies of COVID-19 and contrast-induced nephrotoxicity.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 79770-24-4
Fòrmula: C₃₇H₄₈I₆N₆O₁₈
Peso molecular:1626.23

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Iotrolan Chemical Structure

No. CAS: 79770-24-4

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

Renal RegulationOthers

Renal Regulation

Iotrolan (0-30 min) in the isolated perfused rat kidney produces a maximum GFR decrease of -24.7% and a maximum renal perfusate flow decrease of -21.7%, while increasing urine flow without a sustained fall in fractional sodium reabsorption^[2].

Others

Iotrolan (18.75-150 mg iodine/mL; 1-24 h) exerts direct cytotoxic effects on LLC-PK1 proximal renal tubular cells, reducing MTT conversion to 41% at 75 mg iodine/mL and to 41-50% at 98.5 mM^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[5]

Cell Line:

LLC-PK1 renal tubular cells
Concentration:

18.75-150 mg iodine/mL; 75 mg iodine/mL; 98.5 mM (equal molarity); 98.5 mM (equimolar comparison)
Incubation Time:

1-24 h
Result:

At 75 mg iodine/mL, MTT conversion was 41% of undamaged control cells.
At equal molarity (98.5 mM), MTT conversion was 41%.
At equimolar concentrations (98.5 mM), MTT conversion was 50%.

Related Protocols :

Chemical Information

No. CAS 79770-24-4
Peso molecular 1626.23
Fòrmula C₃₇H₄₈I₆N₆O₁₈
SMILES

O=C(N(C1=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C1I)C)CC(N(C2=C(I)C(C(NC(CO)C(O)CO)=O)=C(I)C(C(NC(CO)C(O)CO)=O)=C2I)C)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kanhed AM, et al. Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach. Molecular diversity. 2021 Feb;25(1):383-401.

[2]. Oldroyd S, et al. Reduced depression of renal function by iotrolan in the isolated rat kidney. European journal of radiology. 1994 Feb;18(1):64-9.

[3]. Rosati G, et al. Clinical utility and safety profile of iomeprol. European journal of radiology. 1994 May;18 Suppl 1:S120-4.

[4]. Fanning NF, et al. Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway. The British journal of radiology. 2002 Nov;75(899):861-73.

[5]. Heinrich MC, et al. Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro. Radiology. 2005 Jun;235(3):843-9.

[6]. Vesga LC, et al. Repurposing of four drugs as anti-SARS-CoV-2 agents and their interactions with protein targets. Scientia Pharmaceutica. 2022 Apr 14;90(2):24.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto