Jun13698
Jun13698 is a SARS-CoV-2 main protease (Mpro) inhibitor with Ki values of 65.6 nM, 510.0 nM, and 117.5 nM against the wild-type, E166V, and E166A mutants, respectively. Jun13698 forms stable complexes with wild-type and mutant Mpro to mediate enzyme inhibition. Jun13698 exhibits antiviral activity against SARS-CoV-2 variants carrying the E166V/A mutation. Jun13698 is applicable to COVID-19-related research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H30F3N3O4S
- Peso molecular:465.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Jun13698 potently inhibits wild-type and Nirmatrelvir (HY-138687)-resistant recombinant SARS-CoV-2 in Vero E6 cells, with an rWT EC50 of 0.08 μM and EC50 values ranging from 0.20 μM to 1.01 μM against the mutant strains. It shows no cytotoxicity even at concentrations as high as 250 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 465.53
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Fòrmula C20H30F3N3O4S
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SMILES
O=C([C@@H]1[C@@]2([H])C(C)(C)[C@@]2([H])CN1C([C@H](C(C)C)NC(C(F)(F)F)=O)=O)N[C@@H](CCSC)C=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Jun13698 Related Classifications
HY-181263 Related Classifications
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