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Referencia número: HY-121372

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Lactandrate

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI₅₀ value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1.

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No. CAS: 43000-65-3
Fòrmula: C₃₁H₄₄Cl₂N₂O₃
Peso molecular:563.60

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lactandrate Chemical Structure

No. CAS: 43000-65-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Estrogen Receptor/ERR :

Cellular Effect

Cell Line	Type	Value	Description	References
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 h by MTT assay Growth inhibition of human MCF7 cells after 48 h by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 by MTT assay Growth inhibition of human MCF7 cells after 48 by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 h by MTT assay Growth inhibition of human T47D cells after 48 h by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 by MTT assay Growth inhibition of human T47D cells after 48 by MTT assay	[PMID: 29649739]

Chemical Information

No. CAS 43000-65-3
Peso molecular 563.60
Fòrmula C₃₁H₄₄Cl₂N₂O₃
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Lactandrate

Ver todos los productos específicos de isoformas Estrogen Receptor/ERR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Lactandrate Related Classifications

HY-121372 Related Classifications