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Referencia número: HY-155851

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Lepadin E

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect.

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No. CAS: 444914-19-6
Fòrmula: C₂₆H₄₇NO₃
Peso molecular:421.66

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lepadin E Chemical Structure

No. CAS: 444914-19-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target

ACSL4

Ver todos los productos específicos de isoformas ACSL Family :

ACSL4
ACSL5

Ver todos los productos específicos de isoformas Glutathione Peroxidase :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.93 μM Compound: Lepadin E	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HeLa	IC₅₀	2.67 μM Compound: Lepadin E	Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HepG2	IC₅₀	6.2 μM Compound: Lepadin E	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
L02	IC₅₀	18.72 μM Compound: Lepadin E	Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MCF7	IC₅₀	5.95 μM Compound: Lepadin E	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MDA-MB-231	IC₅₀	8.04 μM Compound: Lepadin E	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1155	IC₅₀	7.88 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1355	IC₅₀	8.8 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SH-SY5Y	IC₅₀	6.19 μM Compound: Lepadin E	Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SK-OV-3	IC₅₀	7.94 μM Compound: Lepadin E	Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SMMC-7721	IC₅₀	3.93 μM Compound: Lepadin E	Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]

Chemical Information

No. CAS 444914-19-6
Peso molecular 421.66
Fòrmula C₂₆H₄₇NO₃
SMILES

CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
- Marine natural products
- Other marine organisms
- Animals
Tropical Marine Tunicate Didemnum sp.
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Lepadin E

Ver todos los productos específicos de isoformas ACSL Family

Ver todos los productos específicos de isoformas Glutathione Peroxidase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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Lepadin E Related Classifications

HY-155851 Related Classifications