Lerdelimumab
Based on 1 Customer Validation
Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.00%
- No. CAS: 285985-06-0
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Isotype
Human IgG4 lambda
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
TGFB2
In Vitro
Lerdelimumab (10 μg/mL) inhibits all TGF-β2-induced effects. TGF-β2 stimulates transdifferentiation and contraction of the capsular bag and induces MMP-2 and -9 release of capsular bags[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 lambda2
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Lerdelimumab on ProA biosensor, can bind TGF beta 2/TGFB2 Protein, Human (HEK293, HY-P7119) with an affinity constant of 1.927E-09 M as determined in BLI assay.
Chemical Information
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No. CAS 285985-06-0
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Lerdelimumab]
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Synonyms
CAT-152
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Mead AL, et al. Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3394-401. [Content Brief]
[2]. Wormstone IM, et al. TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lerdelimumab Related Classifications
HY-P99695 Related Classifications
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