LY-23
LY-23 is an orally active α-glucosidase inhibitor (Ki = 0.05 μM), with IC50 values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C19H27Cl3O7S
- Peso molecular:505.84
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
LY-23 (72 h) exhibits no significant in vitro cytotoxicity in HEK-293T and L02 cells at concentrations up to 400 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LY-23 (1.0-10.0 mg/kg; p.o.; single administration) reduces postprandial blood glucose in sucrose-loaded mice. At the dose of 1.0 mg/kg, it decreases AUC0-t by 41.5%, while at 10.0 mg/kg, the reduction rate of AUC0-t reaches 48.1%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice (male, SPF grade, 22-26 g)[1]
-
Dosage:1.0 mg/kg
-
Administration:p.o.; single dose
-
Result:Reduced blood glucose levels by 54.3% at 15 minutes.
Reduced blood glucose levels by 58.1% at 30 minutes.
Reduced blood glucose levels by 44.3% at 60 minutes.
Reduced the area under the blood glucose curve (AUC) by 47.1% compared to the control group.
-
Animal Model:ICR mice (male, SPF grade, 22-26 g)[1]
-
Dosage:1.0 mg/kg; 10.0 mg/kg
-
Administration:p.o.; single dose
-
Result:Reduced blood glucose levels by 57.5% at 15 minutes, 53.3% at 30 minutes, 34.3% at 60 minutes, and reduced the AUC by 41.5% compared to the control group (1.0 mg/kg).
Reduced blood glucose levels by 57.0% at 15 minutes, 56.4% at 30 minutes, 47.0% at 60 minutes, and reduced the AUC by 48.1% compared to the control group (10.0 mg/kg).
Chemical Information
-
Peso molecular 505.84
-
Fòrmula C19H27Cl3O7S
-
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)C[S@+]1C[C@H]([C@H]2O[C@H](C)[C@H](OCC3=CC(Cl)=CC=C3Cl)[C@H]2O)O.[Cl-]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY-23 Related Classifications
HY-182289 Related Classifications
Powered by Bioz