MASM7
Based on 5 publication(s) in Google Scholar
MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM.
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- Pureza: 99.85%
- No. CAS: 920868-45-7
- Fòrmula: C22H23N5O2S2
- Peso molecular:453.58
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MASM7
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Actividad biológica
MASM7 (1-10 μM, 2 h) increases Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN[1].
MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1].
MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines[1].
MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h[1].
MASM7 (1 μΜ, 6 h) does not induce caspase-3/7 activation in U2OS cells[1].
MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 920868-45-7
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Appearance Solid
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Peso molecular 453.58
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Fòrmula C22H23N5O2S2
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Color White to yellow
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SMILES
O=C(N)C1=C(SC2=C1CCC2)NC(C(C)SC3=NN=C(C4CC4)N3C5=CC=CC=C5)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Prolif
Targeting ROCK1/YAP1 Axis Ameliorates Inflammation-Induced Prostatic Hyperplasia via Stabilising SIRT1-Dependent Mitochondrial Dynamics. [Abstract]2025 Jul 4:e70085. PMID: 40616266
MASM7 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Jul 4:e70085. [Abstract]
The MFN2 agonist MASM7 (2 μM) significantly impeded the proliferative processes of BPH-1 cells elicited by LPS, manifested as reduced proportions of EdU‐positive proliferative cells.
MASM7 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Jul 4:e70085. [Abstract]
The MFN2 agonist MASM7 (2 μM) reversed the LPS-triggered EMT switch in BPH-1 cells, characterised by the restoration of E-cadherin and the loss of vimentin.
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CNS Neurosci Ther
Downregulation of Mfn2 Contributes to Chronic Postsurgical Pain via Inducing the Pyroptosis of GABAergic Neurons in the Spinal Cord. [Abstract]2025 Jul;31(7):e70508. PMID: 40631358
MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]
MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) reduced the mRNA expression of IL‐1β and IL‐18 in skin/muscle incision and retraction (SMIR) rats compared with vehicle.
MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]
MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) decreased the expression of NLRP3, caspase-1, P20, P10, GSDMD, and GSDMD-N in skin/muscle incision and retraction (SMIR) rats.
MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]
MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) treatment alleviated the mitochondrial morphological injury in spinal neurons of skin/muscle incision and retraction (SMIR) rats. The labeled red boxes highlighted the mitochondrial ultrastructure. The red arrow represented the mitochondria.
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Biomol Biomed
Forkhead box O-1 regulates the biological behavior of BMP-2-induced human bone mesenchymal stem cells through mitochondrial dynamics and autophagy. [Abstract]2025 Mar 7;25(4):869-882. PMID: 39226107 -
Solvente y solubilidad
DMSO : 100 mg/mL (220.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2047 mL | 11.0234 mL | 22.0468 mL | 55.1171 mL |
| 5 mM | 0.4409 mL | 2.2047 mL | 4.4094 mL | 11.0234 mL | |
| 10 mM | 0.2205 mL | 1.1023 mL | 2.2047 mL | 5.5117 mL | |
| 15 mM | 0.1470 mL | 0.7349 mL | 1.4698 mL | 3.6745 mL | |
| 20 mM | 0.1102 mL | 0.5512 mL | 1.1023 mL | 2.7559 mL | |
| 25 mM | 0.0882 mL | 0.4409 mL | 0.8819 mL | 2.2047 mL | |
| 30 mM | 0.0735 mL | 0.3674 mL | 0.7349 mL | 1.8372 mL | |
| 40 mM | 0.0551 mL | 0.2756 mL | 0.5512 mL | 1.3779 mL | |
| 50 mM | 0.0441 mL | 0.2205 mL | 0.4409 mL | 1.1023 mL | |
| 60 mM | 0.0367 mL | 0.1837 mL | 0.3674 mL | 0.9186 mL | |
| 80 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6890 mL | |
| 100 mM | 0.0220 mL | 0.1102 mL | 0.2205 mL | 0.5512 mL |
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