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Referencia número: HY-155011

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MB076

MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with K_i values <1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(-) susceptibility.

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No. CAS: 2832966-95-5
Fòrmula: C₉H₁₂BN₇O₅S₂
Peso molecular:373.18

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MB076 Chemical Structure

No. CAS: 2832966-95-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target

Ki Target: ADC-7, ADC-30, ADC-162, ADC-33, ADC-219, ADC-212^[1]
Ki: 0.21±0.016 μM (ADC-7), 0.058±0.005μM (ADC-30), 0.79±0.039μM (ADC-162), 0.10±0.004μM (ADC-33), 0.11±0.019 (ADC-219), 0.61±0.038μM (ADC-212)^[1]

In Vitro

MB076 (compound B) (0.5-5 μM, 48 h) has an improved stability in human plasma^[1].
MB076 (10 μg/mL, 48 h) acts synergistically in combination with Ceftazidime (CAZ, HY-B0593), and Cefotaxime (CTX, HY-A0088A) to restore pBCSK(−) susceptibility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human Plasma
Concentration:

0.5 μM, 1 μM, 2.5 μM, 4 μM, 5 μM
Incubation Time:

48 h
Result:

Showed excellent stability in human plasma, with a t_1/2 value of 29 h, notably higher than the value obtained for ADC-7/S02030 (PDB4U0X) (9 h).

Chemical Information

No. CAS 2832966-95-5

Peso molecular 373.18

Fòrmula C₉H₁₂BN₇O₅S₂

SMILES

NC1=NN=C(SCC(N[C@H](B(O)O)CN2C=C(C(O)=O)N=N2)=O)S1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Rachel A. Powers, et al. Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J Med Chem. 2023 Jul 13; 66(13): 8510–8525.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Concentration Concentration

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Volume Volume

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MB076 Related Classifications

HY-155011 Related Classifications

Anti-infection

Bacterial

Disease Areas

Infection

Infection

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Keywords

MB076
2832966-95-5
MB 076
MB-076
Bacterial
Inhibitor
inhibitor
inhibit

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