Mitozolomide
Mitozolomide (M & B 39565) is a prodrug of alkyldiazonium reactive intermediates. Mitozolomide can be converted in vivo to triazenes.
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- No. CAS: 85622-95-3
- Fòrmula: C7H7ClN6O2
- Peso molecular:242.62
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | IC50 |
20 μM
Compound: Mitozolomide
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In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZip (mer-)
In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZip (mer-)
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[PMID: 12459014] |
| Fibroblast | IC50 |
30 μM
Compound: Mitozolomide
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In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+)
In vitro cytotoxicity against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+)
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[PMID: 12459014] |
| GM892A cell line | IC50 |
4.8 μM
Compound: 2
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In vitro cytotoxicity against human lymphoblastoid cell line (GM892 A)
In vitro cytotoxicity against human lymphoblastoid cell line (GM892 A)
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[PMID: 7739008] |
| HCT-116 | IC50 |
17.9 μM
Compound: MTZ
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Chemosensitization of p53-deficient human HCT116 cells after 5 days by MTT assay
Chemosensitization of p53-deficient human HCT116 cells after 5 days by MTT assay
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[PMID: 23895620] |
| HCT-116 | IC50 |
60 μM
Compound: MTZ
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Chemosensitization of human HCT116 cells expressing p53 after 5 days by MTT assay
Chemosensitization of human HCT116 cells expressing p53 after 5 days by MTT assay
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[PMID: 23895620] |
| Raji | IC50 |
39 μM
Compound: 2
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In vitro cytotoxicity against Raji cell line
In vitro cytotoxicity against Raji cell line
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[PMID: 7739008] |
| SNB-19 | GI50 |
10 μM
Compound: 2; MTZ
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Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay
Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay
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10.1039/C6MD00384B |
| SNB-19 | GI50 |
68.4 μM
Compound: 2; MTZ
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Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay
Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay
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10.1039/C6MD00384B |
| TLX-5 | IC50 |
2.5 μM
Compound: 2
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In vitro cytotoxicity against mouse TLX5 lymphoma cells
In vitro cytotoxicity against mouse TLX5 lymphoma cells
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[PMID: 7739008] |
| U-373MG ATCC | GI50 |
22 μM
Compound: 2; MTZ
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Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay
Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay
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10.1039/C6MD00384B |
| U-373MG ATCC | GI50 |
40.3 μM
Compound: 2; MTZ
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Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay
Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay
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10.1039/C6MD00384B |
Chemical Information
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No. CAS 85622-95-3
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Appearance Solid
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Peso molecular 242.62
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Fòrmula C7H7ClN6O2
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Color Light brown to brown
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SMILES
O=C(C(N=CN12)=C2N=NN(CCCl)C1=O)N
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Synonyms
M & B 39565; CCRG 81010; NSC 353451
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mitozolomide Related Classifications
HY-106065 Related Classifications
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