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Referencia número: HY-162853

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Mtb-IN-8

Mtb-IN-8 (compound 5jb) is an orally active inhibitor of Mycobacterium tuberculosis (Mtb) with MIC values of 0.03 μg/mL for H37Rv and 0.125-0.06 μg/mL for MDR-Mtb, respectively.

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No. CAS: 2549199-96-2
Fòrmula: C₁₇H₁₈N₄O₅S
Peso molecular:390.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Mtb-IN-8 Chemical Structure

No. CAS: 2549199-96-2

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Mtb-IN-8 (compound 5jb) is an orally active inhibitor of Mycobacterium tuberculosis (Mtb) with MIC values of 0.03 μg/mL for H37Rv and 0.125-0.06 μg/mL for MDR-Mtb, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HK-2	IC₅₀	41.11 μg/mL Compound: 5jb	Cytotoxicity against HK-2 cells incubated for 48 hrs by CCK8 assay Cytotoxicity against HK-2 cells incubated for 48 hrs by CCK8 assay	[PMID: 39166949]
Vero	IC₅₀	>64 μg/mL Compound: 5jb	Cytotoxicity against african green monkey Vero cells incubated for 48 hrs by CCK8 assay Cytotoxicity against african green monkey Vero cells incubated for 48 hrs by CCK8 assay	[PMID: 39166949]

Chemical Information

No. CAS 2549199-96-2
Peso molecular 390.41
Fòrmula C₁₇H₁₈N₄O₅S
SMILES

COC1=CC=C([C@@H]2C(C(NC(SCCC)=N3)=O)=C3NC(C2)=O)C([N+]([O-])=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Sun L,et al. Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido[2, 3-d]pyrimidine-4, 7(3H, 8H)-dione Compounds. J Med Chem. 2024 Sep 12;67(17):14927-14945. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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