MU262
MU262 is a MUS81 inhibitor with an IC50 value of 0.87 μM. MU262 directly inhibits the catalytic activity of MUS81 without interfering with DNA binding, induces genomic instability in tumor cells, and specifically inhibits the HR/BIR repair pathway. The combination of MU262 with Cisplatin (HY-17394) significantly enhances the chemotherapeutic killing effect. MU262 serves as a chemical biology tool for studying MUS81 function, and also acts as a lead compound for the development of anticancer therapies that exploit DNA repair defects in cancer cells.
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- No. CAS: 1846587-13-0
- Fòrmula: C20H15FN6O
- Peso molecular:374.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
MU262 (0.5-5 μM; 0-72 h) inhibits break-induced replication in U2OS BIR-GFP cells with an IC50 of 1.53 μM[1].
MU262 (1-5 μM; 0-72 h) inhibits homologous recombination in U2OS DR-GFP cells[1].
MU262 (3-12 μM; 48 h) induces micronucleus formation in U2OS cells[1].
MU262 (72 h) induces persistent DNA damage in U2OS cells, an effect detectable by increased formation of γH2AX foci[1].
MU262 (administered for 10-12 days) reduces the clonogenic survival rate of U2OS cells[1].
MU262 (2-16 μM; 96-120 h) acts synergistically with Cisplatin (HY-17394) to reduce the viability of U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells
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Concentration:2, 8, 16 μM (in combination with Cisplatin 0-5 μM)
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Incubation Time:96-120 h
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Result:Dose-dependently enhanced cisplatin-induced cytotoxicity, reducing cell viability more effectively than cisplatin alone.
Chemical Information
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No. CAS 1846587-13-0
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Peso molecular 374.37
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Fòrmula C20H15FN6O
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SMILES
OC1=C(C2=NC3=CC=CC=C3N2)N=NC4=C(C5=CC=C(F)C=C5)C(CC)=NN41
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MU262 Related Classifications
HY-181840 Related Classifications
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