Nerylformate
Nerylformate is a terpenoid derivative secreted by American house dust mites (Dermatophagoides farinae) and European house dust mites (Dermatophagoides pteronyssinus). Nerylformate has a significant attraction effect on both male and female individuals of the two species of house dust mites. Nerylformate guides the mites to gather together to reduce dehydration and enhance defense. Nerylformate can be used for the research of immunology and inflammation, such as allergic rhinitis.
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- No. CAS: 2142-94-1
- Fòrmula: C11H18O2
- Peso molecular:182.26
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2142-94-1
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Peso molecular 182.26
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Fòrmula C11H18O2
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SMILES
C/C(C)=C\CC/C(C)=C\COC=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nerylformate Related Classifications
HY-W1121912 Related Classifications
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