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Referencia número: HY-N4329

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Nidulalin A

Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for DNA topoisomerase I. Nidulalin A has certain cytotoxicity.

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No. CAS: 162901-86-2
Fòrmula: C₁₆H₁₄O₆
Peso molecular:302.28

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Nidulalin A Chemical Structure

No. CAS: 162901-86-2

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for DNA topoisomerase I. Nidulalin A has certain cytotoxicity^[1].

Ver todos los productos específicos de isoformas Topoisomerase :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.14 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay	[PMID: 10509910]
K562	IC₅₀	0.32 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay	[PMID: 10509910]
P388	IC₅₀	0.024 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay	[PMID: 10509910]

Chemical Information

No. CAS 162901-86-2
Peso molecular 302.28
Fòrmula C₁₆H₁₄O₆
SMILES

COC([C@]12C(C(C3=C(O)C=C(C)C=C3O2)=O)=CC=C[C@H]1O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Penicillium sp. AJ117292
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Sato S, et al. Inhibition of DNA topoisomerases by nidulalin A derivatives. Biol Pharm Bull. 2000 Apr;23(4):511-2. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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Nidulalin A

Ver todos los productos específicos de isoformas Topoisomerase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Nidulalin A Related Classifications

HY-N4329 Related Classifications