Norgestomet
Based on 1 Customer Validation
Norgestomet is a synthetic 19-nortestosterone-derived progestin analog specifically used for estrus synchronization and reproductive regulation in cattle. Norgestomet reduces the incidence of short luteal phases in postpartum lactating beef cattle, enhances luteal function, and increases the pregnancy rate of timed breeding. Norgestomet suppresses estrus during embryo implantation, synchronizes the timing of estrus resumption, and improves the calving rate of first timed artificial insemination in pubertal beef heifers.
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- No. CAS: 25092-41-5
- Fòrmula: C23H32O4
- Peso molecular:372.50
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Norgestomet (3.0-6.0 mg; intramuscular injection, ear implant; retained for 9 days) increases the timed artificial insemination pregnancy rate to 14% in pre-synchronized, postpartum lactating beef cows with anestrus, and to 22% in pre-synchronized, postpartum lactating beef cows with normal estrous cycles[1].
Norgestomet (10 mg per administration; subcutaneous implantation in the ear; 2 administrations total; lasting 12 days) increases the calving rate of the first artificial insemination to 55%, synchronizes the estrous cycle of non-pregnant cows, and does not impair the luteal function of pregnant cows[2].
Norgestomet (3.6 mg; subcutaneous ear implant; for 12 consecutive days) increases the calving rate of the first artificial insemination to 45%, achieves complete estrus synchronization in non-pregnant cows, improves cumulative fertility in the early breeding season, and does not impair corpus luteum function in pregnant cows[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hereford and Angus (2 to 10 years of age, 420 to 510 kg, postpartum suckled, anestrous or cyclic, estrus synchronized via two prostaglandin F2α injections 11 days apart)[1]
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Dosage:6 mg
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Administration:ear implant; left in situ for 8 days
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Result:Reduced the incidence of abnormal luteal phases from 78% to 21%.
Increased ovulation rate to 100%.
Increased timed breeding pregnancy rate to 46% in presynchronization anestrous cows.
Increased timed breeding pregnancy rate to 100% in presynchronization cyclic cows.
Increased timed breeding pregnancy rate to 59% when anestrous and cyclic cows were combined.
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Animal Model:Postpartum suckled beef cows (25 to 90 days postpartum, managed on fescue pasture with corn silage or fescue hay, anestrous or cyclic, estrus synchronized via Syncro-Mate B)[1]
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Dosage:3.0 mg (in combination with 5.0 mg estradiol valerate); 6.0 mg
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Administration:i.m. injection; ear implant; left in situ for 9 days
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Result:Achieved a timed breeding pregnancy rate of 14% without additional GnRH in presynchronization anestrous cows.
Achieved a timed breeding pregnancy rate of 22% without additional GnRH in presynchronization cyclic cows.
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Animal Model:Beef heifers (Angus or Angus-Hereford × Simmental; 12 to 14 months old; 250 to 425 kg; good body condition; initially synchronized with Syncro-Mate B, then artificially inseminated ~47 hours after initial implant removal)[2]
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Dosage:20.0 mg total
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Administration:s.c. ear implant; day 9 after initial timed AI to day 21 after initial AI
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Result:Increased calving rate to initial timed AI to 55%.
Restricted estrus during implantation to only 1 of 9 nonpregnant treated heifers.
Achieved 83% of nonpregnant treated heifers returning to estrus in the peak 3-day period.
Extended average estrous cycle length to 22.0 days.
Showed no significant difference in serum progesterone concentrations between treated and control pregnant heifers on day 21.
Achieved 90% accuracy of progesterone concentration on day 21 for determining pregnancy status.
Chemical Information
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No. CAS 25092-41-5
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Appearance Solid
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Peso molecular 372.50
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Fòrmula C23H32O4
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Color Off-white to light yellow
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SMILES
CC([C@]1(CC[C@]2([C@@]3(CCC4=CC(CC[C@@]4([C@]3([C@H](C[C@]12C)C)[H])[H])=O)[H])[H])OC(C)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Norgestomet Related Classifications
HY-121677 Related Classifications
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