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Referencia número: HY-172915

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p53 Stabilizer 2

p53 Stabilizer 2 is a 9'-cycloheptylselenomethyl-noscapine derivative and DNA-PKcs-dependent p53 stabilizer with low tubulin-binding affinity.p53 Stabilizer 2 induces S-phase arrest and apoptosis in cancer cells.p53 Stabilizer 2 can be used for the research of cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2531685-87-5
Fòrmula: C₃₀H₃₇NO₇Se
Peso molecular:602.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

p53 Stabilizer 2 Chemical Structure

No. CAS: 2531685-87-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

p53 Stabilizer 2 (compound 17a16) exerts potent proliferation-inhibitory effects on various tumor cell lines including JeKo-1 and MOLM-13. The IC₅₀ at 48 h (0.81-1.81 μM) is lower than that of normal peripheral blood mononuclear cells, conferring excellent tumor selectivity^[1].
p53 Stabilizer 2 increases mitochondrial superoxide levels in A375 and JeKo-1 cells, and induces cellular oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines
Concentration:

IC₅₀ assay
Incubation Time:

48 h
Result:

Exhibited IC₅₀ values of 0.92 ± 0.04, 1.81 ± 0.03, 1.36 ± 0.10, 0.97 ± 0.03, 1.71 ± 0.60, and 0.81 ± 0.10 μM against MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines, respectively.

Chemical Information

No. CAS 2531685-87-5
Peso molecular 602.58
Fòrmula C₃₀H₃₇NO₇Se
SMILES

O=C1O[C@H]([C@@H]2N(C)CCC3=C(C[Se]C4CCCCCC4)C5=C(OCO5)C(OC)=C23)C6=C1C(OC)=C(OC)C=C6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Li D, et al. Discovery of novel and highly potent anticancer agents enabled by selenium scanning of noscapine. Eur J Med Chem. 2025;293:117714. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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