PCSK9 modulator-2
PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-2 has the potential for the research of hyperlipidemia.
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- No. CAS: 2365416-53-9
- Fòrmula: C17H12F2N2
- Peso molecular:282.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
201.7 nM
Compound: 16
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Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
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[PMID: 31227343] |
Chemical Information
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No. CAS 2365416-53-9
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Peso molecular 282.29
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Fòrmula C17H12F2N2
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SMILES
FC1=CC=CC2=C1NC=C2CC3=CC4=CC(F)=CC=C4N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCSK9 modulator-2 Related Classifications
HY-128334 Related Classifications
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