PD-134672
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
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- No. CAS: 135704-06-2
- Fòrmula: C33H52N6O7S2
- Peso molecular:708.93
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Chemical Information
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No. CAS 135704-06-2
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Peso molecular 708.93
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Fòrmula C33H52N6O7S2
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SMILES
O=S(N[C@H](C(N[C@H](C(N[C@@]([C@@H](O)[C@@H](O)CC(C)C)([H])CC1CCCCC1)=O)CC2=CSC(N)=N2)=O)CC3=CC=CC=C3)(N4CCOCC4)=O
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Synonyms
CI-992
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-134672 Related Classifications
HY-19145 Related Classifications
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