RG7112D
RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels.
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- No. CAS: 2360561-90-4
- Fòrmula: C36H42Cl2N4O4
- Peso molecular:665.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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MDM2 |
Chemical Information
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No. CAS 2360561-90-4
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Peso molecular 665.65
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Fòrmula C36H42Cl2N4O4
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SMILES
O=C(CN1CCN(CC1)C(N2[C@](C3=CC=C(C=C3)Cl)([C@](C4=CC=C(C=C4)Cl)(N=C2C5=CC=C(C=C5OCC)C(C)(C)C)C)C)=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RG7112D Related Classifications
HY-158685 Related Classifications
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