RS5517
Based on 1 Customer Validation
RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.79%
- No. CAS: 2227017-46-9
- Fòrmula: C23H19ClN2O2
- Peso molecular:390.86
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
0.1 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| DLD-1 | IC50 |
0.5 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
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[PMID: 30996786] |
| DLD-1 | IC50 |
65 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
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[PMID: 30996786] |
| LS174T | IC50 |
52 μM
Compound: 15
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Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
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[PMID: 30996786] |
| LS174T | IC50 |
8 μM
Compound: 15
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Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
0.1 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
0.9 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
8 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
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[PMID: 30996786] |
| SW-620 | IC50 |
0.5 μM
Compound: 15
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Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| SW-620 | IC50 |
18 μM
Compound: 15
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Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
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[PMID: 30996786] |
Chemical Information
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No. CAS 2227017-46-9
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Appearance Solid
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Peso molecular 390.86
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Fòrmula C23H19ClN2O2
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Color White to light yellow
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SMILES
O=C(C1=C(CC2=CC=CC=C2)C3=C(C=CC(Cl)=C3)N1)NC4=CC=C(CO)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Saponaro C, et al. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. Oncogene. 2018 Jun;37(24):3301-3316. doi: 10.1038/s41388-018-0170-y. Epub 2018 Mar 19. [Content Brief]
[2]. Capdevielle C, et al. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53. Neuro Oncol. 2020 Apr 15;22(4):550-562. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RS5517 Related Classifications
HY-150269 Related Classifications
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