SAE-14
Based on 1 publication(s) in Google Scholar
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
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- Pureza: 98.60%
- No. CAS: 1241280-25-0
- Fòrmula: C19H19F3N2O2
- Peso molecular:364.36
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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- Referencias
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Publications Citing Use of MedChemExpress (MCE) SAE-14
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Actividad biológica
IC50: 28.5 nM (GPR183)[1]
SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC50 value below 50 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:The human leukemia (HL)-60 cells
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Concentration:5×of the antagonist
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Incubation Time:15 min
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Result:Had GPR183-specific (IC50: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female ICR mice[1]
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Dosage:2.9 µM
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Administration:intrathecal (i.th.) injections; 2.9 µM; once
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Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.
Chemical Information
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No. CAS 1241280-25-0
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Appearance Solid
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Peso molecular 364.36
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Fòrmula C19H19F3N2O2
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Color White to off-white
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SMILES
O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
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Synonyms
GPR183 antagonist-1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion. [Abstract]2023 Jun 21;954:175872. PMID: 37353188
Solvente y solubilidad
DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7445 mL | 13.7227 mL | 27.4454 mL | 68.6135 mL |
| 5 mM | 0.5489 mL | 2.7445 mL | 5.4891 mL | 13.7227 mL | |
| 10 mM | 0.2745 mL | 1.3723 mL | 2.7445 mL | 6.8613 mL | |
| 15 mM | 0.1830 mL | 0.9148 mL | 1.8297 mL | 4.5742 mL | |
| 20 mM | 0.1372 mL | 0.6861 mL | 1.3723 mL | 3.4307 mL | |
| 25 mM | 0.1098 mL | 0.5489 mL | 1.0978 mL | 2.7445 mL | |
| 30 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2871 mL | |
| 40 mM | 0.0686 mL | 0.3431 mL | 0.6861 mL | 1.7153 mL | |
| 50 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL | |
| 60 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1436 mL | |
| 80 mM | 0.0343 mL | 0.1715 mL | 0.3431 mL | 0.8577 mL | |
| 100 mM | 0.0274 mL | 0.1372 mL | 0.2745 mL | 0.6861 mL |
SAE-14 Related Classifications
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