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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
complement factor D
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "complement factor D" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: ACH-4471
Target:
Áreas de investigación:
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
2
2 Cited Publications
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Target:
Áreas de investigación:
Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
Synonyms: BCX9930
Target:
Áreas de investigación:
Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases .
Referencia número: HY-NP004
Synonyms: CVF
Target:
Áreas de investigación:
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
Referencia número: HY-P990952
No. CAS: 2527079-60-1
Synonyms: OMS906
Target:
Áreas de investigación:
Target:
Áreas de investigación:
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .
Target:
Áreas de investigación:
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
Referencia número: HY-P99298
No. CAS: 1278466-20-8
Synonyms: RG 7417; TNX 234; Anti-CFD Recombinant Antibody
Target:
Áreas de investigación:
Target:
Áreas de investigación:
Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .
Referencia número: HY-163684
No. CAS: 2243483-63-6
Target:
Áreas de investigación:
Zoracopan is a selective complement factor D (CFD) inhibitor. When administered systemically (orally or intravenously), Zoracopan accumulates and is sustained-released in ocular tissues, primarily in the choroid-retinal pigment epithelium (C-RPE) and/or iridociliary body (I-CB) .
Referencia número: HY-177123
No. CAS: 2922808-66-8
Target:
Áreas de investigación:
Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM. Refinicopan inhibits hemolysis of rabbit red blood cells. Refinicopan can be used to study diseases mediated by complement factor D .
Referencia número: HY-P2830
No. CAS: 37213-56-2
Target:
Áreas de investigación:
Complement factor D is a serine protease. Complement factor D activates C3 convertase by specifically cleaving complement Factor B. Complement factor D is promising for research of autoimmune diseases (e.g., paroxysmal nocturnal hemoglobinuria, C3 glomerulopathy), age-related macular degeneration, and thrombotic microangiopathies .
Referencia número: HY-172239
No. CAS: 2378381-06-5
Target:
Áreas de investigación:
Tarvicopan is an inhibitor for complement factor D .
Referencia número: HY-W049802
No. CAS: 918531-01-8
Target:
Áreas de investigación:
Referencia número: HY-102034R
No. CAS: 1386455-76-0
Target:
Áreas de investigación:
Complement factor D-IN-1 (Standard) is the analytical standard of Complement factor D-IN-1 (HY-102034). This product is intended for research and analytical applications. Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
Referencia número: HY-P990955
No. CAS: 2839652-75-2
Synonyms: ADX-097
Target:
Áreas de investigación:
Referencia número: HY-P71726
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cfd; Adn; Df; complement factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D
Species:
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Protocols
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