Secutrelvir
Based on 1 Customer Validation
Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC50 values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.64%
- No. CAS: 2996148-73-1
- Fòrmula: C23H16Cl2F3N5O2
- Peso molecular:522.31
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Anti-Infection Compound Library
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Antiviral Compound Library
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Protease Inhibitor Library
HY-L147
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Multi-Target Compound Library
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
Secutrelvir (S-892216) exhibits antiviral activity against multiple SARS-CoV-2 strains (including Omicron variants) in VeroE6/TMPRSS2 cells with an EC50 range of 2.27 to 12.5 nmol/L[1].
Secutrelvir (S-892216) exhibits antiviral activity against multiple SARS-CoV-2 strains (including Omicron variants) in hAECs with an EC90 range of 2.31 to 2.41 nmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Secutrelvir (0.1-10 mg/kg; p.o.; twice daily; 5 days) exhibits dose-dependent therapeutic efficacy against COVID-19 in SARS-CoV-2-infected Syrian hamsters, including up to 2.9-log reductions in lung virus titers and 2.3-log reductions in nasal turbinate virus titers at the 10 mg/kg dose, plus suppression of lung inflammation and body weight loss[2].
S-892216 (0.1-10 mg/kg; p.o.; twice daily; 2 days) exhibits potent dose-dependent antiviral efficacy against SARS-CoV-2 Gamma strain in BALB/cAJcl mice, with maximum efficacy achieved at 3 mg/kg twice daily, and equivalent activity to ensitrelvir at a 32-fold lower dose[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Syrian hamsters (intranasally inoculated with SARS-CoV-2 Omicron BE.1/BA.5-like)[2]
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Dosage:0.1 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; twice daily; 5 days
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Result:Reduced lung virus titer by 1.9-log and nasal turbinates virus titer by 1.8-log at 1 mg/kg, measured 3 days post-infection.\nReduced lung virus titer by 2.9-log and nasal turbinates virus titer by 2.3-log at 10 mg/kg, measured 3 days post-infection.\nSuppressed SARS-CoV-2-induced lung inflammation and body weight loss in a dose-dependent manner.
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Animal Model:BALB/cAJcl (female, 5 weeks of age, intranasally inoculated with SARS-CoV-2 Gamma strain)[3]
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Dosage:0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:p.o.; twice daily; 2 days
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Result:Achieved statistically significant reduction in lung virus titers at 0.3 mg/kg.\nReached maximum efficacy at 3 mg/kg, with viral titers reduced to near the lower limit of quantification (LLOQ = 1.80 log10 TCID50/mL).\nAchieved viral titer reduction comparable to the ensitrelvir 32 mg/kg group at 1 mg/kg.
Chemical Information
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No. CAS 2996148-73-1
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Appearance Solid
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Peso molecular 522.31
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Fòrmula C23H16Cl2F3N5O2
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Color White to off-white
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SMILES
N#CCN1C(N(C2=CC(Cl)=CN=C2)C(C(C3=CC(Cl)=C(F)C=C3)=C1N4CC5(CC(F)(C5)F)C4)=O)=O
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Synonyms
S-892216
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (191.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9146 mL | 9.5729 mL | 19.1457 mL | 47.8643 mL |
| 5 mM | 0.3829 mL | 1.9146 mL | 3.8291 mL | 9.5729 mL | |
| 10 mM | 0.1915 mL | 0.9573 mL | 1.9146 mL | 4.7864 mL | |
| 15 mM | 0.1276 mL | 0.6382 mL | 1.2764 mL | 3.1910 mL | |
| 20 mM | 0.0957 mL | 0.4786 mL | 0.9573 mL | 2.3932 mL | |
| 25 mM | 0.0766 mL | 0.3829 mL | 0.7658 mL | 1.9146 mL | |
| 30 mM | 0.0638 mL | 0.3191 mL | 0.6382 mL | 1.5955 mL | |
| 40 mM | 0.0479 mL | 0.2393 mL | 0.4786 mL | 1.1966 mL | |
| 50 mM | 0.0383 mL | 0.1915 mL | 0.3829 mL | 0.9573 mL | |
| 60 mM | 0.0319 mL | 0.1595 mL | 0.3191 mL | 0.7977 mL | |
| 80 mM | 0.0239 mL | 0.1197 mL | 0.2393 mL | 0.5983 mL | |
| 100 mM | 0.0191 mL | 0.0957 mL | 0.1915 mL | 0.4786 mL |
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