Sinococuline
Based on 1 Customer Validation
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.29%
- No. CAS: 109351-36-2
- Fòrmula: C18H23NO5
- Peso molecular:333.38
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
37 μM
Compound: 9
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Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane
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[PMID: 20426456] |
| Hepatocyte | IC50 |
4.5 μM
Compound: 2
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Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
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[PMID: 18456502] |
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells[1].
Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection[1]
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Dosage:0.5, 1.0, 2.0 mg/kg/day
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Administration:I.p. twice a day for 5 days
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Result:Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day.
The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
Chemical Information
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No. CAS 109351-36-2
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Appearance Solid
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Peso molecular 333.38
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Fòrmula C18H23NO5
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Color White to off-white
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SMILES
COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4O)C[C@H](O)[C@@H]1O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sinococuline Related Classifications
HY-N11096 Related Classifications
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