Sorbinil
Based on 2 publication(s) in Google Scholar
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.08%
- No. CAS: 68367-52-2
- Fòrmula: C11H9FN2O3
- Peso molecular:236.20
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Sorbinil
More
Actividad biológica
Descripciòn
In Vitro
Sorbinil (10 μM; 24 h) results an aldose reductase inhibition and attenuates LPS-induced oxidative stress/ROS production in Raw264.7 murine macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 68367-52-2
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Appearance Solid
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Peso molecular 236.20
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Fòrmula C11H9FN2O3
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Color White to off-white
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SMILES
O=C([C@@]12C3=CC(F)=CC=C3OCC1)NC(N2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Regen Biomater
Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin. [Abstract]2024 Mar 1:11:rbae020. PMID: 38529352 -
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (423.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Huang Q, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Med Chem. 2019;15(1):3-7. [Content Brief]
[2]. Chang KC, et al. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25;202(1-3):283-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2337 mL | 21.1685 mL | 42.3370 mL | 105.8425 mL |
| 5 mM | 0.8467 mL | 4.2337 mL | 8.4674 mL | 21.1685 mL | |
| 10 mM | 0.4234 mL | 2.1169 mL | 4.2337 mL | 10.5843 mL | |
| 15 mM | 0.2822 mL | 1.4112 mL | 2.8225 mL | 7.0562 mL | |
| 20 mM | 0.2117 mL | 1.0584 mL | 2.1169 mL | 5.2921 mL | |
| 25 mM | 0.1693 mL | 0.8467 mL | 1.6935 mL | 4.2337 mL | |
| 30 mM | 0.1411 mL | 0.7056 mL | 1.4112 mL | 3.5281 mL | |
| 40 mM | 0.1058 mL | 0.5292 mL | 1.0584 mL | 2.6461 mL | |
| 50 mM | 0.0847 mL | 0.4234 mL | 0.8467 mL | 2.1169 mL | |
| 60 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7640 mL | |
| 80 mM | 0.0529 mL | 0.2646 mL | 0.5292 mL | 1.3230 mL | |
| 100 mM | 0.0423 mL | 0.2117 mL | 0.4234 mL | 1.0584 mL |
Sorbinil Related Classifications
HY-50289 Related Classifications
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