Symplostatin 1
Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides.
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- No. CAS: 212007-18-6
- Fòrmula: C43H70N6O6S
- Peso molecular:799.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A10 | EC50 |
0.6 nM
Compound: 2
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Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence
Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence
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[PMID: 11473421] |
| HT-29 | IC50 |
1.5 nM
Compound: Symplostatin 1
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Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
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[PMID: 20806908] |
| KB | IC50 |
0.15 nM
Compound: 2
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 11473421] |
| KB | IC50 |
0.3 ng/mL
Compound: 2
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 9748368] |
| LoVo | IC50 |
0.34 nM
Compound: 2
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Cytotoxicity against human LoVo cells
Cytotoxicity against human LoVo cells
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[PMID: 11473421] |
Chemical Information
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No. CAS 212007-18-6
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Peso molecular 799.12
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Fòrmula C43H70N6O6S
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SMILES
O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@H]([C@@]3([H])N(CCC3)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)[C@@H](C)CC)=O)=O)=O)OC
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Structure Classification
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Initial Source
Cyanobacterium Symploca hydnoides
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Symplostatin 1 Related Classifications
HY-125453 Related Classifications
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