Terbucarb
Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione.
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- No. CAS: 1918-11-2
- Fòrmula: C17H27NO2
- Peso molecular:277.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Terbucarb (27.7-277 μg/mL; 48 h) significantly induces the formation of micronuclei and multinucleated cells in hamster lung cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 (male, 8 weeks old, 30 g)[1]
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Dosage:1000 mg/kg
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Administration:p.o.; single dose
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Result:Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 24 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 3.0 per 1000 reticulocytes at 48 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 72 hours post-treatment.
Demonstrated no statistically significant increase in micronucleated reticulocyte frequencies relative to the concurrent corn oil control group at all time points.
Chemical Information
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No. CAS 1918-11-2
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Peso molecular 277.41
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Fòrmula C17H27NO2
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SMILES
O=C(OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C)NC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Terbucarb Related Classifications
HY-W721611 Related Classifications
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