Thymol iodide
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Thymol iodide is an iodine derivative of thymol, serving as a mild preservative and fungicide. Thymol iodide is commonly used as an iodine source in the intensive culture of rotifers. Thymol iodide effectively enables Brachionus "Cayman" rotifers to reach iodine levels similar to those of copepods, and maintains a high iodine content during storage. After 28 days of intrapleural injection of Thymol iodide, it does not enhance the efficacy of inducing pleurodesis in rabbits, nor does it improve the efficacy of talc slurry pleurodesis.
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- No. CAS: 552-22-7
- Fòrmula: C20H24I2O2
- Peso molecular:550.21
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Actividad biológica
Descripciòn
In Vivo
Thymol iodide (0.3-25.2 g/kg feed; mixed with enrichment feed; 3 h enrichment) can efficiently enrich the iodine content of rotifers to a level comparable to that of copepods via an extremely low proportion of dietary replacement (accounting for 0.36-2.03% of the total diet), and maintains a stable iodine retention rate when stored at room temperature or low temperature for up to 18 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand white (male)[1]
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Dosage:50 mg (as part of iodized talc slurry with 200 mg/kg talc)
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Administration:intrapleural injection; single dose
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Result:Recorded mean pleural fluid volume of 2.2 mL at 48 hours post-injection.
Reported mean gross pleurodesis adhesion score of 2.3 and mean microscopic pleural fibrosis score of 2.0 on day 28.
Found 30% of rabbits (3/10) had a good pleurodesis (score 3 or 4) on day 14 and 30% (3/10) on day 28.
Observed no significant differences in pleural fluid characteristics, gross adhesion scores, microscopic inflammation scores, or microscopic fibrosis scores compared to plain talc controls at any time point.
Chemical Information
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No. CAS 552-22-7
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Appearance Solid
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Peso molecular 550.21
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Fòrmula C20H24I2O2
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Color Light yellow to yellow
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SMILES
CC(C1=C(OI)C=C(C)C(C2=CC(C(C)C)=C(OI)C=C2C)=C1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble)
H2O : < 0.1 mg/mL (insoluble)
* Thymol iodide is usually formulated as a suspension.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (537 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)