Thyroglobulin
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Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell.
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- Pureza: 93%
- No. CAS: 9010-34-8
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
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Thyroglobulin (0-10 mg/mL; 12 h to 5 days) stimulates cell growth and DNA synthesis in quiescent FRTL-5 thyroid cells, with maximal activity at 5 mg/mL and reduced activity at higher concentrations[1].
Thyroglobulin (5 mg/mL; 12 h) does not increase cAMP levels in FRTL-5 thyroid cells[1].
Thyroglobulin (5 mg/mL; 30-180 min) activates Akt kinase activity in FRTL-5 thyroid cells within 30 min[1].
Thyroglobulin (0-10 mg/mL) suppresses TPO promoter activity in FRTL-5 thyroid cells in vitro in a concentration-dependent manner[1].
Thyroglobulin (0-10 mg/mL; 24 h) modulates PDS mRNA expression in FRTL-5 thyroid cells, with maximal expression at 5 mg/mL and reduced expression at higher concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rat FRTL-5 thyroid cells
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Concentration:5 mg/mL (cell counting; maximal ³H-TdR incorporation); 0-10 mg/mL (³H-TdR concentration dependence)
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Incubation Time:up to 5 days (cell counting); 12 h (³H-TdR incorporation)
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Result:Increased cell number to levels comparable to complete medium (TSH + insulin + 5% serum) over 5 days using 5 mg/mL. Maximized ³H-TdR incorporation at 5 mg/mL, and reduced incorporation at 10 mg/mL.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 9010-34-8
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Appearance Solid
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Color Light brown to brown
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SMILES
[Thyroglobulin]
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Synonyms
Thyroglobulin from bovine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
H2O : 50 mg/mL (Need ultrasonic)
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thyroglobulin Related Classifications
HY-107903 Related Classifications
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